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Scott Phillips

  • Assistant Professor of Chemistry
104 Chemistry Building
Room 436
Phone: (814) 867-2502

Research Interests

Design and synthesis of molecules with unique function; unconventional reaction methodology; analytical and bioanalytical chemistry; environmental chemistry; materials chemistry.

Chemistry for Resource-Limited Environments

We are using organic chemistry to create “autonomous diagnostics”—that is, diagnostic devices that provide all of the functions typically obtained with instruments (selectivity, sensitivity, quantitative measurements, and clearly displayed information), but using only organic reactions on a piece of paper.  Our goal is to devise chemistry that forms the basis for exceedingly simple and disposable diagnostics devices.  These systems will be useful in the developing world, emergency rooms, and other applications requiring portable and inexpensive devices for detecting disease or pollution.


Unconventional Reaction Methodology

As the price of crude oil continues to rise, so too will prices of bulk chemicals derived from oil.  We are developing reactions that use CO2 as an inexpensive carbon source (in place of oil) for making bulk chemical building blocks.

A second program in this area focuses on reaction networks that are self-perpetuating, the simplest of which is an autocatalytic reaction (where a molecule makes more of itself).  We plan to expand autocatalytic behavior into more complex reaction networks, with the goal of developing systems that provide useful function and/or byproducts.

Designing “Living” Materials

We are developing materials that respond to external signals by changing shape, function, and/or surface properties.  This work can be extended to developing materials that grow, and possibly divide.

Scott Phillips
  • B.S., California State University, San Bernardino, 1999
  • Ph.D., University of California, Berkeley, 2004
  • Martarano Career Development Professor
  • Beckman Young Investigator, 2009
  • Thieme Chemistry Journal Awardee, 2009
  • DARPA Young Faculty Award, 2009
  • Camille and Henry Dreyfus New Faculty Award, 2008
  • NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow 2007–2008 (Harvard University).
  • Damon Runyon Cancer Research Foundation Postdoctoral Fellow, 2004–2007 (Harvard University).
  • Eli Lilly Graduate Fellowship, 2002–2004
  • Boehringer Ingelheim Pharmaceutical Inc. Fellowship, 2001–2002
  • Barry M. Goldwater Scholarship, 1998

Representative Publications

Simple Telemedicine for Developing Regions: Camera Phones and Paper-Based Microfluidic Devices for Real-Time, Off-Site Diagnosis.  Martinez, A. W.; Phillips, S. T.; Carrilho, E.; Thomas, S. W.; Sindi, H.; Whitesides, G. M.  Anal. Chem. 2008, 80, 3699-3707.

Patterned Paper as a Platform for Inexpensive, Low Volume, and Portable Bioassays.  Martinez, A. W.; Phillips, S. T.; Butte, M.; Whitesides, G. M.  Angew. Chem. Int. Ed. Eng. 2007, 46, 1318–1320.

Density-Based Diamagnetic Separation: Devices for Detecting Binding Events and for Collecting Unlabeled Diamagnetic Particles in Paramagnetic Solutions.  Winkleman, A.; Perez-Castillejos, R.; Gudikson, R.; Phillips, S. T.; Prentiss, M.; Whitesides, G. M.  Anal. Chem. 2007, 79, 6542–6550.

Ritterazine Natural Products: Synthesis, Kinetic Analysis, and Reassignment of Ritterazine 5,5-Spiroketals.  Phillips, S. T.; Shair, M. D.  J. Am. Chem. Soc. 2007, 129, 6589–6598.

Quantifying the Interactions that Contribute to b-Hairpin Folding.  Phillips, S. T.; Piersanti, G.; Bartlett, P. A.  Proc. Natl. Acad. Sci., USA 2005, 102, 13737–13742.

@-Tides as Reporters for Molecular Associations.  Phillips, S. T.; Blasdel, L. K.; Bartlett, P. A.  J. Am. Chem. Soc. 2005, 127, 4193–4198.

@-Tides: The 1,2-Dihydro-3(6H)-pyridinone Unit as a b-Strand Mimic.  Phillips, S. T.; Rezac, M.; Abel, U.; Kossenjans, M.; Bartlett, P. A.  J. Am. Chem. Soc. 2002, 124, 58–66.


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