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David Boehr

  • Assistant Professor of Chemistry
Email: ddb12@psu.edu

Research Interests

The goal of the Boehr lab will be to rigorously delineate the role of protein dynamics in enzyme function, coordination and regulation using biochemical and biophysical techniques, and apply this information towards improving structure-based drug design and protein engineering.  The main tool to analyze enzyme dynamics will be nuclear magnetic resonance (NMR) that allows site-specific structural and dynamic detail across 1017 orders of magnitude (10-12 – 105 seconds).


David Boehr
  • B.Sc., University of Lethbridge, Canada, 1993
  • NSERC of Canada Predoctoral Fellowship, 1998-2003
  • Ph.D., McMaster University, Canada, 2004
  • Canadian Institutes of Health Research (CIHR), Postdoctoral Fellowship 2004-2007
  • Post-doc, The Scripps Research Institute, 2008

Representative Publications

Boehr, D.D., McElheny, D., Dyson, H.J. and Wright, P.E. The dynamic energy landscape of dihyrofolate reductase catalysis. Science, 2006, 313, 1638-1642.

Boehr, D.D., Dyson, H.J and Wright, P.E. An NMR perspective on enzyme dynamics. Chem. Rev., 2006, 3055-3079.
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