Mass Spec

The Proteomics and Mass Spectrometry Core Facility (PMCF) provides the Penn State community with expertise and cutting edge technologies in mass spectrometry and proteomics. The facility is equipped with the state-of-the-art instrumentation. Analyses of variety of samples including synthetic compounds, polymers, biomolecules such as proteins, peptides, sugars, and oligonucleotides are available to the Penn State community. Among the routine services offered by our "Small Molecule" unit are nominal and accurate molecular weight determinations and LC-MS and GC-MS of mixtures. Recently established "Proteomics" division offers 2D gel electrophoresis, sample preparation for MS analysis (Spot picking, protein digestion, desalting), image analysis using PDQuest, protein identification by tandem mass spectrometry (nano LC-MS/MS), protein identification by peptide mass fingerprinting (MALDI-MS), post-translational modification analysis (non-routine), de novo peptide sequencing by tandem mass spectrometry. The major mass spectrometry instruments, most of which are recently acquired, are two nano LC-ESI-MS/MS system (Micromass Q-Tof micro, Micromass Q-Tof API US), two LC-ESI-MS system (Perseptive Biosystems Mariner, Micromass LCT Premier), two MALDI instruments (Perseptive Voyager DE-STR, Micromass MALDI-L/R), a GC-MS (Micromass GCT), and a triple quadrupole mass spectrometer (Finnigan TSQ700). In addition, complete setup to perform 2D gel based protein is available. For information on sample submission and other related issues, visit the facility website. For non-routine research needs and for consultation, please make an appointment with the facility staff.

Interim Director: Eric Snyder
ems9@psu.edu
Phone: 814/865-8202
Location: 317 Chemistry Building
Web Site